The Israeli Air Force says it has launched a fresh wave of fighter jet attacks on Iran.(Supplied: Israeli Air Force via X.)
The Israeli Air Force has confirmed that a fresh wave of air force fighter jet attacks was launched on Iranian "military infrastructure" in the country's south-west.
At least 430 people have died in Iran, according to state media reports, and at least 24 people have died in Israel as a result of the conflict between the two countries.
French President Emmanuel Macron has vowed to accelerate nuclear negotiations with Iran in a bid to pursue peace.
Israel's air force has confirmed that a fresh wave of air force jet attacks has been launched towards Iran, as the conflict between the two countries enters into its second week.
The air force says the fighter jets were deployed on Saturday local time to target "military infrastructure" in south-western Iran.
Israel also says it has killed a veteran Iranian commander during attacks by both sides in the more than week-long air conflict, while Tehran said it would not negotiate over its nuclear programme while under threat.
Deep below a mountain in Iran sits a once-secret uranium enrichment facility which is threatening to drag the United States into the Israel-Iran conflict.
Saeed Izadi, who led the Palestine Corps of the Quds Force, the Iranian Revolutionary Guards' overseas arm, was killed in a strike on an apartment in the Iranian city of Qom, said Israeli Defence Minister Israel Katz.
Calling his killing a "major achievement for Israeli intelligence and the Air Force", Mr Katz said in a statement that Izadi had financed Hamas ahead of its October 7, 2023, attack on Israel, which triggered the war in Gaza.
The Revolutionary Guards said five of its members died in attacks on Khorramabad, according to Iranian media. They did not mention Izadi, who was on US and British sanctions lists.
Iranian media said earlier on Saturday that Israel had attacked a building in Qom, with initial reports of a 16-year-old killed and two people injured.
Thousands of people in Tehran have been injured as a result of the conflict.(West Asia News Agency: Majid Asgaripour via Reuters)
At least 430 people have been killed and 3,500 injured in Iran since Israel began its attacks on June 13, Iranian state-run Nour News said, citing the health ministry.
In Israel, 24 civilians have been killed by Iranian missile attacks, according to local authorities, in the worst conflict between the longtime enemies.
Israel says Iran was on the verge of developing nuclear weapons, while Iran says its atomic programme is only for peaceful purposes.
An Israeli air defence system intercepts missiles over Tel Aviv during an Iranian attack.(AP: Leo Correa)
Israel is widely assumed to possess nuclear weapons, which it neither confirms nor denies.
Iranian Foreign Minister Abbas Araqchi said Israel's aggression, which he said had indications of US involvement, should stop so Iran can "come back to diplomacy".
With a few words, Donald Trump waves away the advice of the entire US spy infrastructure and its assessment that Iran was not trying to build a nuclear weapon.
"It is obvious that I can't go to negotiations with the US when our people are under bombardments under the support of the US," he told reporters in Istanbul where he was attending a meeting of the Organisation of Islamic Cooperation (OIC).
On Friday in Geneva, Mr Araqchi met European foreign ministers who were seeking a path back to diplomacy.
US President Donald Trump said he would take up to two weeks to decide whether the United States should enter the conflict on Israel's side, enough time "to see whether or not people come to their senses", he said.
He said on Friday he thought Iran would be able to have a nuclear weapon "within a matter of weeks, or certainly within a matter of months", adding: "We can't let that happen."
On Saturday, French President Emmanuel Macron said he had spoken with Iranian President Masoud Pezeshkian about the Iranian nuclear program.
Iran's Fars news agency said Israel had targeted the Isfahan nuclear facility, one of the nation's biggest, but there was no leakage of hazardous materials. Israel said it had launched a wave of attacks against missile storage and launch infrastructure sites.
The International Atomic Energy Agency )IAEA) later confirmed the strike at Isfahan, saying it hit a centrifuge manufacturing workshop.
“We know this facility well. There was no nuclear material at this site and therefore the attack on it will have no radiological consequences,” IAEA Director-General Grossi said in a statement.
Ali Shamkhani, a close ally of Iran's supreme leader, also said he had survived an Israeli attack.
"It was my fate to stay with a wounded body, so I stay to continue to be the reason for the enemy's hostility," he said in a message carried by state media.
Early on Saturday, the Israeli military warned of an incoming barrage from Iran, triggering air raid sirens across parts of central Israel and in the Israeli-occupied West Bank.
Interceptions were visible in the sky over Tel Aviv, with explosions echoing as Israel's air defence systems responded. There were no reports of casualties.
The Human Rights Activists News Agency, a US-based rights organisation that tracks Iran, gave a higher death toll than Tehran, saying Israeli attacks have killed 639 people there.
Those killed in Iran include the military's top echelon and nuclear scientists. Israel said it also killed a second commander of the Guards' overseas arm, whom it identified as Benham Shariyari, during an overnight strike.
Nour News on Saturday named 15 air defence officers and soldiers it said had been killed in the conflict with Israel.
Iran's health minister, Mohammadreza Zafarqandi, said Israel has attacked three hospitals during the conflict, killing two health workers and a child, and has targeted six ambulances, according to Fars.
When asked about the reports, an Israeli military official said that only military targets were being struck, though there may have been collateral damage in some incidents.
An Iranian missile hit a hospital in the southern Israeli city of Beersheba on Thursday.
At the OIC meeting, where the Israel-Iran conflict topped the agenda, Turkish President Tayyip Erdogan said Israel's attacks on Iran right before a planned new round of nuclear talks with the US aimed to sabotage negotiations and showed Israel did not want to resolve issues through diplomacy.
The Geneva talks produced little signs of progress, and Mr Trump said he doubted negotiators would be able to secure a ceasefire because "Iran doesn't want to speak to Europe. They want to speak to us."
Mr Trump said he was unlikely to press Israel, its close ally, to scale back its air strikes to allow negotiations to continue in part because it was "winning".
Iran has spent decades building its "Axis of Resistance" across the Middle East, but its allies have been largely silent since Israel launched a series of attacks last week.
"But we're ready, willing and able, and we've been speaking to Iran, and we'll see what happens," he said.
Israel has said it will not stop attacks until it dismantles Iran's nuclear programme and ballistic missile capabilities, which it views as an existential threat.
A senior Iranian official told Reuters that Iran was ready to discuss limitations on uranium enrichment but that it would reject any proposal that barred it from enriching uranium completely, "especially now under Israel's strikes".